Changing the Program
Reprogramming murine Müller glia to drive photoreceptor genesis and restoration of vision
Ruth Steer |
Müller glia cells, abundant in the retina, are known to support retinal cell function. But they also have another support function: retinal regeneration. In cold-blooded vertebrates, such as zebrafish, it is well known that Müller glia can act as a source of stem cells to induce retinal repair and regeneration. But this regenerative capacity is absent in mammals; although cell proliferation might occur in response to injury, these cells do not repair or regenerate the retina. Now, a team from Icahn School of Medicine at Mount Sinai, New York, USA, have shown that they were able to reprogram Müller glia to generate rod photoreceptors, and restore light perception in a mouse model of congenital blindness (1).
Read the full article now
Log in or register to read this article in full and gain access to The Ophthalmologist’s entire content archive. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Ophthalmologist magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.