3D Printing for Retinal Implants

A study published in Translational Vision Science & Technology has introduced the 3D-Printed Large-Array Port-System (3D-PLAPS), a novel implantation device designed to enhance the surgical implantation of large epiretinal stimulators used for treating retinal dystrophies, such as retinitis pigmentosa (RP).

Researchers from RWTH Aachen University, Germany, developed 3D-PLAPS using computer-aided design (CAD) software and 3D printing techniques, before testing the device in cadaveric porcine and rabbit eyes. In their tests, they evaluated surgical feasibility, intraocular pressure (IOP) stability, and potential benefits in epiretinal stimulator implantation.

Key design features of 3d-PLAPS include: an elliptical aperture for precise implantation, a closing plug to prevent ocular fluid leakage, and pre-implantation templates to ensure accurate positioning.

The study found that 3D-PLAPS successfully stabilized IOP during surgery, reducing the risk of hypotonia and intraocular fluid turbulence. The device also sealed the incision site, allowing for controlled positioning and adjustment of the implant without additional surgical steps. It also enabled the implantation of large-area epiretinal stimulators developed by the group, such as Very Large Electrode Arrays (VLARS), helping to reduce trauma to the eye.

Interestingly, the authors note that the RGD525 3D-printing material used to create the devices is biocompatible, reducing the risk for intraocular inflammation. While they recommend that further in vivo experiments are now needed to validate 3D-PLAPS’ use in future surgical procedures, in this study, the authors note how they successfully managed to demonstrate how the device could be “implanted and explanted without threatening the structural integrity of the eye.”