The Power List 2016
Professor of Physiology and Professor and Vice-Chair of Ophthalmology and Visual Sciences at the University of Kentucky
Jayakrishna’s principal research interest is to identify the molecular mechanisms that underlie the development of AMD, determine the triggers that convert this disease from an atrophic to a neovascular phenotype, and develop novel therapeutics to prevent and treat the disease. His lab was the first to demonstrate the presence of in situ complement activation in the retina and choroid of patients with AMD, and his groundbreaking research on the mechanisms that control cell death and vascular growth has led to fundamental insights into the factors that lead to AMD development. His group also developed a new therapy for the treatment of dry AMD, which they are planning to test in clinical trials.