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The Ophthalmologist / Issues / 2026 / September / The Anatomy of Disagreement
Anterior Segment Cornea Discussion

The Anatomy of Disagreement

The second Global Consensus on Keratoconus and Ectatic Diseases records what 128 experts from six continents now agree on. But what they don't agree on forms a map of everything the field still cannot standardize, and why

By Farhad Hafezi, José A. P. Gomes , Renato Ambrósio Jr., Mark Hillen 9/25/2026 4 min read

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Clinical Report: The Anatomy of Disagreement

Overview

The second Global Consensus on Keratoconus and Ectatic Diseases highlights significant disagreements among experts regarding key diagnostic metrics and definitions. Notably, while Kmax is widely used, its reliability is questioned.

Background

The second edition of the Global Consensus, involving 128 ophthalmologists, aims to address critical areas such as diagnosis, treatment, and surgical interventions.

Data Highlights

No numerical data presented in the article.

Key Findings

  • 91.7% of the diagnostic panel agreed that Kmax has low repeatability and reproducibility for evaluating progression.
  • 75% of panelists still use Kmax in daily practice despite its unreliability.
  • A new staging system for keratoconus was developed based on the Belin ABCD grading.
  • The panel could not reach consensus on definitions for 'subclinical keratoconus' and 'forme fruste keratoconus.'
  • 71% endorsed biomechanical assessment as a valuable adjunct in refractive surgery screening.

Clinical Implications

Clinicians should be aware of the limitations of Kmax as a progression parameter and consider alternative metrics for evaluating keratoconus. The updated definitions and staging systems may guide more accurate diagnosis and treatment planning.

Conclusion

The second Global Consensus on Keratoconus and Ectatic Diseases reveals critical areas of disagreement.

Related Resources & Content

  1. Cornea, 2026 -- Global Consensus on Keratoconus and Ectatic Diseases-Edition 2
  2. Ophthalmology, 2021 -- Effect of Corneal Cross-linking versus Standard Care on Keratoconus Progression in Young Patients
  3. Eye, 2024 -- Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: 5-year outcomes from the Save Sight Keratoconus Registry
  4. the analytical scientist — The Power of Passionate Debate
  5. inside dentistry — Dissecting the Debate Over the Ethics of Esthetic Dentistry
  6. Journal of General Internal Medicine — Exploring Decision-Making Thresholds: Insights on Judgment and Educational Approaches
  7. the analytical scientist — Addressing a State of Disunion
  8. The Power of Passionate Debate
  9. Dissecting the Debate Over the Ethics of Esthetic Dentistry
  10. Exploring Decision-Making Thresholds: Insights on Judgment and Educational Approaches
  11. Global Consensus on Keratoconus and Ectatic Diseases-Edition 2 - PubMed
  12. Effect of Corneal Cross-linking versus Standard Care on Keratoconus Progression in Young Patients - Ophthalmology
  13. Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: 5-year outcomes from the Save Sight Keratoconus Registry | Eye
  14. Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care - PMC

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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