5 Key Takeaways

• 1

  A combination of levofloxacin and ibuprofen may enhance treatment for bacterial keratitis amid rising antimicrobial resistance.

• 2

  In a rat model, combination therapy outperformed monotherapy in microbiological, molecular, and histological assessments.

• 3

  Ibuprofen reduced the minimum inhibitory concentration of levofloxacin, indicating enhanced antibacterial potency.

• 4

  Combination therapy resulted in lower inflammatory cytokine expression and improved corneal architecture compared to monotherapy.

• 5

  The study's findings are exploratory, limited by small sample size and focus on Staphylococcus aureus, necessitating further research.