Objective:
To evaluate the efficacy of a combination of levofloxacin and ibuprofen in treating bacterial keratitis.
Key Findings:
- Combination therapy outperformed monotherapy across microbiological, molecular, and histological endpoints.
- Ibuprofen reduced the minimum inhibitory concentration (MIC) of levofloxacin by up to eightfold.
- Ibuprofen exhibited anti-biofilm activity, reducing Staphylococcus aureus biofilm formation.
- Combination-treated corneas showed the lowest expression of inflammatory cytokines and reduced TLR4 activation.
- Histological analysis revealed near-normal corneal architecture in the combination group.
Interpretation:
Limitations:
- Small sample size and short treatment duration.
- Reliance on transcriptional rather than protein-level analyses.
- Only Staphylococcus aureus was evaluated, limiting broader applicability.
Conclusion:
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