The Science Behind Epi-On
Clinical trials evaluate the safety and efficacy of epithelium-off corneal collagen cross-linking treatment protocols with supplemental oxygen
Michael B. Raizman | | Longer Read
Epithelium-off (epi-off) corneal collagen cross-linking (CXL) has been effective in stabilizing keratoconus, offering hope to many patients with this progressive condition (1).Epithelium-on (epi-on) CXL, in which the epithelium is minimally disturbed, has historically not been as successful, but clinicians and researchers continue to explore this option, believing it may reduce the risk of infection and corneal haze (2).
Although the risk of these complications in epi-off procedures is low (1, 3), striving to further improve safety is always a worthwhile goal. In addition, patients undergoing an epi-on procedure may experience less postoperative discomfort and faster visual recovery.
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