Shifting the AMD Burden-Benefit Balance
Aflibercept’s newly approved administration regime permits a reduction in intravitreal injection frequency – and recent clinical trial data (ALTAIR) suggest that extended interval dosing can sustain robust vision gains over 2 years
Rod McNeil | | Hot Topic
At a Glance
- The ALTAIR trial recently provided evidence to support new aflibercept treatment regimen
- Eight-weekly aflibercept dosing was associated with 96-week efficacy and safety outcomes similar to those of a monthly ranibizumab regime
- Later intervals varied from 8 to 16 weeks, the interval being adjusted on the basis of individual patient characteristics
- Treat-and-extend dosing earlier in the first year of aflibercept treatment has resulted in excellent visual outcomes, and reduced burden of treatment for many patients.
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