Cookies

Like most websites The Ophthalmologist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Subspecialties Cornea / Ocular Surface, Basic & Translational Research

Root of the Problem

A study has uncovered a potential therapeutic target for one of ophthalmology’s most unusual conditions: Sjögren’s syndrome. Most common in women between the ages of 40 and 60, the disease sees the exocrine glands become infiltrated with lymphocytes, instigating severe damage to the salivary and lacrimal glands. The researchers compared samples from patients with Sjögren’s syndrome and healthy controls, and found that those with the condition had abnormally high levels of microRNA-744 – a molecule blocking the production of anti-inflammatory mediator Pellino3 (PELI3).

By downregulating microRNA-744 expression, the researchers were able to reduce ocular inflammation. “Our research provides the opportunity to treat the root cause of the disease, rather than just the symptoms,” said co-author Joan Ní Gabhann-Dromgoole, Senior Scientist at the Royal College of Surgeons in Dublin, Ireland.

Subscribe to The Ophthalmologist Newsletters

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].

  1. Q Pilson et al., Nature, 10, 7484 (2020). PMID: 32366870.

About the Author

Phoebe Harkin

Associate Editor of The Ophthalmologist

I’ve always loved telling stories. So much so, I decided to make a job of it. I finished a Masters in Magazine Journalism and spent three years working as a creative copywriter before itchy feet sent me (back)packing. It took seven months and 13 countries, but I’m now happily settled on The Ophthalmologist, where I’m busy getting stuck into all things eyeballs.

Related Case Studies

The Missing Piece of the Dry Eye Puzzle

| Contributed by Quidel

Uncovering Ocular Comorbidity

| Contributed by Quidel

Finding Ocular Surface Inflammation

| Contributed by Quidel

Product Profiles

Access our product directory to see the latest products and services from our industry partners

Here

Register to The Ophthalmologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Ophthalmologist magazine

Register