Subscribe to Newsletter
Subspecialties Neuro-ophthalmology, Comprehensive, Retina, COVID-19

Recharging After Long COVID

The variable presentation of long COVID symptoms might just be the biggest mystery of the pandemic. Initial infection with SARS-CoV-2 is already a mixed bag of symptoms – especially with variants changing the picture – but long COVID also appears to result in a scattered array of cognitive issues, likely caused by infiltration of the central nervous system (CNS). Along with changes in attention, tiredness, memory, and basic comprehension of language, a manifestation of particular note for ophthalmologists is vision impairment.

Symptoms can last for weeks or months, with no treatment currently available. But recent research has uncovered that alternating non-invasive brain stimulation (NIBS) significantly improved the vision and cognition of two patients in just three days (1). The effective “recharging” of the vasculature and neurons affected by long COVID partially reversed visual field loss and increased cognition – and the two patients were even able to return to work.

The probable cause of both visual and cognitive long COVID symptoms is through vascular dysfunction – the retina being an obvious source of damage from disruption at the blood-retinal barrier. NIBS was considered as a potential treatment for visual impairment because of a previous study in glaucoma patients, in which most participants gained vision improvement after the treatment (2). 

The authors believe the neurological deficits in cognition and sight that arise from long COVID are due to hypometabolism in neurons – which are rejuvenated by the NIBS treatment. Perhaps just as importantly, this strong indication of a vascular and neuronal pathology to long COVID could be further investigated to develop other effective treatments. Of course, the positive findings need to be assessed in much larger cohorts and, ultimately, a clinical trial setting before more concrete conclusions can be made about NIBS effectiveness. Nevertheless, given the serious dearth of long COVID treatments available, NIBS at least represents an interesting and non-invasive potential option.

Receive content, products, events as well as relevant industry updates from The Ophthalmologist and its sponsors.

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. BA Sabel et al., Restor Neurol Neurosci, 39, 408 (2022). PMID: 34924406.
  2. C Gall et al., PLoS One, 11, e0156134 (2016). PMID: 27355577.
About the Author
Geoffrey Potjewyd

Associate Editor, The Ophthalmologist

The lion’s share of my PhD was spent in the lab, and though I mostly enjoyed it (mostly), what I particularly liked was the opportunity to learn about the latest breakthroughs in research. Communicating science to a wider audience allows me to scratch that itch without working all week only to find my stem cell culture has given up the ghost on the Friday (I’m not bitter). Fortunately for me, it turns out writing is actually fun – so by working for Texere I get to do it every day, whilst still being an active member of the clinical and research community.

Product Profiles

Access our product directory to see the latest products and services from our industry partners

Register to The Ophthalmologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Ophthalmologist magazine



The Ophthalmologist website is intended solely for the eyes of healthcare professionals. Please confirm below: