Pouring Oil on Troubled Retinas
Silicone oil tamponades can inhibit scar tissue formation in patients with a high risk of retinal scarring after retinal detachment. But how much more effective would these products be, if they also delivered antifibrotics?
Victoria Kearns | | Longer Read
At a Glance
- Replacing the vitreous with silicone oil can reduce scar tissue formation in vitreoretinopathy and diabetic retinopathy, but attempts to combine the oil with pharmaceuticals have not yet been successful
- A multidisciplinary team at the University of Liverpool, UK, is working on achieving controlled drug release from silicone tamponades to prevent retinal scarring
- Milestones of the research so far include choosing the right model drug and determining its solubility in oil, as well as modulating the release kinetics of oil-drug combinations
- The team has proven that modified silicone oils are non-toxic to relevant cells, they enhance drug solubility and extend drug release.
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