Swimming Against the Nucleotides
Advances in cell and gene therapy have led to a spate of novel treatments for inherited retinal disease. But with each breakthrough comes new dilemmas...
Mariya Moosajee | | Longer Read
(Not) Going Viral
Plasmid vectors are gaining traction as a viable alternative in gene therapy delivery
I’m currently working on non-viral gene therapy, which – I believe – will be the second wave of therapies in this field. This alternative approach uses plasmid vectors, which are composed of entirely human elements that can package the gene, and deliver it to target organs. Non-viral gene therapy has not traditionally been considered as effective as the use of viral vectors because of the cell’s ability to silence plasmid vectors after a short time, meaning that they are no longer able to express the gene of interest.
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