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Subspecialties Retina, Basic & Translational Research

Swimming Against the Nucleotides

(Not) Going Viral

Plasmid vectors are gaining traction as a viable alternative in gene therapy delivery

I’m currently working on non-viral gene therapy, which – I believe – will be the second wave of therapies in this field. This alternative approach uses plasmid vectors, which are composed of entirely human elements that can package the gene, and deliver it to target organs. Non-viral gene therapy has not traditionally been considered as effective as the use of viral vectors because of the cell’s ability to silence plasmid vectors after a short time, meaning that they are no longer able to express the gene of interest.

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About the Author

Mariya Moosajee

Mariya Moosajee is a Consultant Ophthalmologist and Associate Professor at Moorfields Eye Hospital, Great Ormond Street Hospital for Children and UCL Institute of Ophthalmology, London, UK.

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