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Subspecialties Basic & Translational Research, Retina, Neuro-ophthalmology

Bitesize Breakthroughs

  • Researchers at Augusta University have discovered a potential treatment path for patients with optic nerve trauma. The team used a mouse model to show that removing the inflammatory enzyme arginase 2, which increases with injury, decreases neuron death in the retina, as well as the degeneration of nerve fibers that connect neurons in the brain. In fact, brain-derived neurotropic factor increased upon removing A2, suggesting that the axons were attempting to repair themselves and, ultimately, to reconnect with the brain. The team are now pursuing several new lines of investigation into the role of A2 in optic nerve injuries, for which there is currently no targeted therapy (1).

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About the Author

Phoebe Harkin

Associate Editor of The Ophthalmologist

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