A study into the retinal membranes of rodents attempts to shed light on autosomal dominant Stargardt disease and age-related macular degeneration
Phoebe Harkin |
Stargardt-like macular dystrophy is an inherited disease caused by a mutation in the gene controlling the synthesis of certain polyunsaturated fatty acids (PUFAs). The disease (caused by a mutations of the elongation of very-long-chain fatty acids-4 –or ELOVL4 gene) mainly affects the cone-photoreceptor-rich macula of the eye and results in a loss of central vision – but a question remains: why are rod cells in the peripheral retina – which also require PUFAs for normal signaling – not affected? With the help of a few furry friends, a team from the University of Oklahoma Health Sciences Center tried to find (part of) the answer.
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