5 Key Takeaways

• 1

  A prospective study followed 67 eyes from 36 participants with glaucoma for an average of 2.2 years to assess whether the water-drinking test predicted progression.

• 2

  After participants drank 1 L of water within 5 minutes, investigators measured IOP at baseline and 15, 30, and 45 minutes.

• 3

  Eyes with a water-drinking test peak IOP above 21 mmHg had faster visual field mean deviation loss and retinal nerve fiber layer thinning.

• 4

  Among 59 eyes with acceptable office IOP, 22 (37%) exceeded 21 mmHg during the test and showed faster functional and structural deterioration.

• 5

  The findings are exploratory because the cohort was modest, follow-up averaged just over 2 years, treatment changes were uncontrolled, and larger multicenter studies are needed.