5 Key Takeaways
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1
A drug-eluting contact lens co-delivering PDRN and DMPC accelerated corneal epithelial healing and improved tear film stability in rabbit models.
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2
In the corneal wound model, mean residual defect area on day 2 was 0.37% with the combination lens and 4.46% with the control lens.
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3
On day 3, regenerated epithelium was thicker with PDRN plus DMPC than with the control lens (28.33 μm vs 14.82 μm).
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4
In the dry eye model, tear break-up time increased to 15.1 seconds by day 7 with the combination lens, compared with 8.0 seconds with the control lens.
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5
The short, nonrandomized animal study did not isolate the effects of PDRN, DMPC, or the lens, and the findings require evaluation in humans.
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