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The Ophthalmologist / Issues / 2026 / March / Beyond IOP: The Mood Effects of CAIs
Glaucoma Interview Research & Innovations

Beyond IOP: The Mood Effects of CAIs

Evidence from large US dataset suggests topical carbonic Anhydrase Inhibitors may increase depression risk in glaucoma patients

3/12/2026 3 min read

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  • Top Institutions
Top Institutions in Ophthalmology

Leading ophthalmology research centers utilize large-scale patient data analysis, clinical observation, and pharmacovigilance studies to investigate the neuropsychiatric side effects of glaucoma medications, combining clinical trials with real-world evidence from collaborative health networks.

  • #1

    Bascom Palmer Eye Institute

    Miami, FL

    Renowned for pioneering glaucoma research and clinical trials, Bascom Palmer has extensive expertise in studying the systemic and neuropsychiatric effects of ophthalmic medications, supported by leadership in large-scale data analysis and patient-centered outcomes.

    Key Differentiators

    • Ophthalmology
    • Glaucoma Research
    • Neuro-ophthalmology
  • #2

    Massachusetts Eye and Ear Infirmary

    Boston, MA

    A top academic center with a strong focus on glaucoma pathophysiology and treatment side effects, known for integrating clinical research with neuropsychiatric assessments in ophthalmic drug safety.

    Key Differentiators

    • Ophthalmology
    • Glaucoma
    • Neuro-ophthalmology
  • #3

    Johns Hopkins Wilmer Eye Institute

    Baltimore, MD

    Wilmer Eye Institute is a leader in ophthalmic pharmacology and glaucoma research, with a strong emphasis on understanding systemic effects of topical eye medications and their impact on patient quality of life.

    Key Differentiators

    • Ophthalmology
    • Glaucoma
    • Pharmacology
  • #4

    University of California, San Francisco (UCSF) Department of Ophthalmology

    San Francisco, CA

    UCSF is recognized for its comprehensive glaucoma research programs and clinical trials focusing on medication safety and patient-reported outcomes, including mental health effects of glaucoma therapies.

    Key Differentiators

    • Ophthalmology
    • Glaucoma
    • Clinical Research

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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