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The Ophthalmologist / Issues / 2026 / January / Optimizing nAMD Treatment with AI
Latest Retina Interview

Optimizing nAMD Treatment with AI

Jeffry Hogg and Pearse Keane discuss how AI might be used to detect existing treatment gaps in age-related macular degeneration

1/2/2026 5 min read

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Clinical Report: Optimizing nAMD Treatment with AI

Overview

Recent research indicates that artificial intelligence (AI) can effectively minimize both undertreatment and overtreatment of neovascular age-related macular degeneration (nAMD). The study emphasizes the importance of training AI models on diverse imaging devices to enhance diagnostic accuracy.

Background

Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss in older adults, necessitating accurate and timely treatment. The integration of AI in ophthalmology presents an opportunity to improve patient outcomes by supporting clinicians in decision-making processes. Understanding the implications of AI in nAMD treatment is crucial as the prevalence of AMD is projected to rise significantly in the coming decades.

Data Highlights

No numerical data was provided in the source material.

Key Findings

  • AI can reduce both undertreatment and overtreatment of nAMD.
  • Training AI on multiple OCT systems is essential to avoid performance issues due to domain shift.
  • AI systems are envisioned to function as decision-making support tools rather than autonomous operators.
  • Collaboration between AI and clinicians enhances diagnostic accuracy and management plans.
  • Patient engagement and trust are critical for the acceptance of AI in treatment decisions.

Clinical Implications

Clinicians should consider integrating AI tools into their practice to enhance diagnostic accuracy and treatment planning for nAMD. Ongoing education and patient engagement will be essential to foster trust in AI-assisted decision-making.

Conclusion

The application of AI in nAMD treatment holds promise for improving patient care, but careful consideration of its implementation and the role of clinicians is necessary for optimal outcomes.

References

  1. Haseltine W, Hazel K, Retinal Physician, 2024 -- Artificial Intelligence to Manage the AMD Burden
  2. Madabhushi A, Abraham J, ASCO Post, 2024 -- AI in Cancer Care: Embrace the Change
  3. Neurosymbolic, Multiagent AI Speeds Oncology Clinical Trial Matching by Fourfold, ASCO AI, 2026
  4. npj Digital Medicine — A Self-Directed Approach for Identifying Cognitive Issues in Clinical Settings Utilizing Large Language Models

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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