Objective:
To estimate the probability of high myopia-associated glaucomatous or glaucoma-like optic neuropathy (GLON) and non-glaucomatous optic neuropathy (NGON) using data from the Two-Continent Eye Study.
Approach:
- Study Design: The study analyzed data from five population-based cohorts, including 35,167 eyes from 17,996 individuals aged six to 100 years.
- Assessment Methods: Participants underwent refractometry, ocular biometry, optic nerve and macular photography, OCT, and perimetry.
- Definitions: GLON was defined by glaucomatous optic nerve head abnormalities; NGON was defined by normal rim configuration with signs of optic atrophy.
- Statistical Analysis: The study population was divided into development and validation cohorts to derive and validate equations for estimating GLON and NGON probabilities.
Key Findings:
- GLON was present in 2.7% of eyes and NGON in 0.3%.
- Most GLON eyes had intraocular pressure of 21 mm Hg or below.
- In the validation cohort, equations achieved areas under the ROC curve of 0.881 for GLON and 0.964 for NGON.
- Estimated GLON probability for a non-Indian individual with axial length of 28 mm increased from 3.5% at age 30 to 60.2% at age 75.
Interpretation:
The equations provide estimates of optic nerve risk in highly myopic patients, particularly those with long axial lengths.
Limitations:
- The data are cross-sectional rather than longitudinal.
- Axial length was assumed to remain constant over time.
- The model was not externally validated.
- Other factors, such as family history of glaucoma, were not included.
Conclusion:
The study provides a framework for assessing optic nerve risk in highly myopic patients.
Sources:
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
