Macular hole patients in Africa often present late with advanced disease, showing unique surgical responses compared to other demographics. A study revealed that 54% of Black African patients had large macular holes averaging 500 microns. Factors such as stronger vitreoretinal adhesion and a more adherent internal limiting membrane (ILM) contribute to the distinctive characteristics of African eyes. The formation of eccentric macular holes (EMHs) in temporal regions was noted, prompting a reevaluation of surgical techniques to optimize patient outcomes.
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