Dry eye disease (DED) significantly affects older individuals, with 5–30% prevalence in those over 65. The complexities of treating DED in older patients arise from interrelated factors including age-related physiological changes, systemic conditions, and changes in medication. Careful assessment of each patient's health history ensures tailored treatment plans that address not only the DED but also other health considerations, such as diabetes or autoimmune disorders. Effective management includes adapting medication choices and ensuring the practicality of therapy for the patient's capabilities.
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