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Our December/January cover feature takes a look at the little-known condition, Charles Bonnet Syndrome (CBS), which produces vivid hallucinations in sufferers, and is a disturbing side effect of sight loss. Judith Potts tells the story about how this condition affected her own mother, Esme, and how she is on a mission to raise awareness through her charity Esme’s Umbrella. We also learn about a new monoclonal antibody treatment for thyroid eye disease, the use of Lucentis in preterm infants with ROP, and how CorneaGen is set to end our dependence on donor tissue. Arthur Cummings argues that the field of ophthalmology needs to embrace refractive surgery, and urges like-minded physicians to join the Refractive Surgery Alliance (RSA). We also hear from some of the most innovative companies in ophthalmology as they present their latest offerings in our Innovators 2019 feature. The In Practice section sees Philip Bloom discuss how combining inflow and outflow procedures could help combat glaucoma, and John Sparrow highlights the benefits of the Royal College of Ophthalmologists National Ophthalmology Database (RCOphth NOD) audit. In our NextGen section, we delve into quantum dots and how they could improve outcomes for retinitis pigmentosa patients. Finally, we sit down with Audrey Talley Rostov to hear about her humanitarian work and her advice for budding ophthalmologists.