When Imaging Isn’t Enough
Molecular biomarker analysis could improve the diagnosis and management of keratoconus, and might only require tear fluid
Swaminathan Sethu, Natasha Pahuja, Rohit Shetty |
From least to greatest severity, keratoconus can be managed with interventions ranging from spectacles, contact lenses, intracorneal ring segments, corneal collagen crosslinking (CXL) or corneal transplants – usually with reasonable success. But a significant proportion of patients continue to deteriorate or progress to severe disease, despite getting the best possible treatment. Why? In many cases, the problem begins with diagnosis. This shows us two clear unmet needs: early detection of keratoconus, and a better understanding of why some patients don’t respond to treatment.
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