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Subspecialties Refractive

Unlock the Surrogates

The importance of adequate monitoring and management of glaucoma needs no reinforcement. Glaucoma-related death of retinal ganglion cells (RGCs) cannot be reversed: early diagnosis is therefore critical, as without timely detection, therapeutic intervention may be too late to prevent permanent vision loss. Yet our options for screening and monitoring the progression of this disease, particularly in its early stages, are profoundly unsatisfactory – and glaucoma remains one of the leading causes of blindness worldwide. How might we resolve this situation? In my view, development of molecular biomarkers – quantifiable surrogates of disease progression and therapeutic response – could transform the management of this most problematic disease.

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About the Author

Rajendra S. Apte

Rajendra S. Apte is a Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences, Developmental Biology and Medicine, at the Washington University School of Medicine, MO, USA

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