Unlock the Surrogates
Current methods of diagnosing and monitoring glaucoma sometimes fail physicians and patients alike – could molecular biomarkers open the door to better outcomes?
Rajendra S. Apte |
The importance of adequate monitoring and management of glaucoma needs no reinforcement. Glaucoma-related death of retinal ganglion cells (RGCs) cannot be reversed: early diagnosis is therefore critical, as without timely detection, therapeutic intervention may be too late to prevent permanent vision loss. Yet our options for screening and monitoring the progression of this disease, particularly in its early stages, are profoundly unsatisfactory – and glaucoma remains one of the leading causes of blindness worldwide. How might we resolve this situation? In my view, development of molecular biomarkers – quantifiable surrogates of disease progression and therapeutic response – could transform the management of this most problematic disease.
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