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Subspecialties Basic & Translational Research, Retina, COVID-19

The SCOPE of Things to Come

Dry AMD is the most common cause of blindness among the elderly, affecting between 36 and 40 million people globally, according to the 2010 Access Economics Report. Right now, there are no approved treatments. The SCOPE study run by Gyroscope Therapeutics is a global natural history study enrolling participants at approximately 60 sites globally, including centers throughout the UK, including the London Vision Clinic (1).

It is a prospective, observational protocol designed to evaluate the natural progression of anatomical and functional visual parameters in genetically defined patients with Geographic Atrophy (GA). We plan to genotype 2,000 people – preferably more – at our network of centers throughout the country, with the goal of identifying patients with mutations in their Complement Factor I (CFI) gene. The study will allow the characterization of patient phenotype, including disease progression. It is, in a word, groundbreaking.

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About the Author

Paulo Eduardo Stanga

Retina Service Lead, Consultant Ophthalmologist and Vitreoretinal Surgeon at the London Vision Clinic, UK

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