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Subspecialties Glaucoma, Basic & Translational Research

The Rhythm of the Night

Intraocular pressure (IOP) is affected by both posture and circadian rhythm – with peak IOPs achieved at night when people are both supine and sleeping. Accordingly, nocturnal IOP control is an important part of glaucoma management, yet some topical glaucoma medications like brimonidine tartrate and timolol maleate fail to significantly reduce nighttime IOP. A drug that can control IOP when patients are sleeping (and therefore not administering eyedrops) would certainly be worth having.

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