Conexiant
Login
  • Corneal Physician
  • Glaucoma Physician
  • New Retinal Physician
  • Ophthalmology Management
  • Ophthalmic Professional
  • Presbyopia Physician
  • Retinal Physician
The Ophthalmologist
  • Explore

    Explore

    • Latest
    • Insights
    • Case Studies
    • Opinion & Personal Narratives
    • Research & Innovations
    • Product Profiles

    Featured Topics

    • Anterior Segment
    • Glaucoma
    • Retina

    Issues

    • Latest Issue
    • Archive
  • Subspecialties
    • Cataract
    • Cornea
    • Glaucoma
    • Neuro-ophthalmology
    • Oculoplastics
    • Pediatric
    • Retina
  • Business

    Business & Profession

    • Professional Development
    • Business and Entrepreneurship
    • Practice Management
    • Health Economics & Policy
  • Training & Education

    Career Development

    • Professional Development
    • Career Pathways

    Events

    • Webinars
    • Live Events
  • Events
    • Live Events
    • Webinars
  • Community

    People & Profiles

    • Power List
    • Voices in the Community
    • Authors & Contributors
  • Multimedia
    • Video
    • Podcasts
Subscribe
Subscribe

False

Advertisement
The Ophthalmologist / Issues / 2018 / Nov / Squalamine on Trial
Research & Innovations

Squalamine on Trial

11/26/2018 1 min read

Share

Squalamine may have fascinating origins – originally derived from the livers of the dogfish shark – but as a treatment for wet AMD it has so far failed to have any “bite.” An antiangiogenic steroid, this small molecule drug has been shown to stop the growth of abnormal blood vessel development and reduce vascular endothelial growth factor (VEGF), showing potential in cancer therapies as well as in treatment for macular diseases.

Initial trials discovered that it inhibited neovascularization in the iris when injected intravenously, and was found to induce regression of retinopathy in mouse models.

In 2012, Ohr Pharmaceutical commenced a clinical trial assessing the effectiveness of squalamine when combined with Lucentis injections. 128 patients were given monthly Lucentis injections, and asked to use either squalamine (0.2 percent) or placebo eye drops over a nine-month period in the multi-center, randomized, double-masked clinical trial. Assessment was carried out monthly via eye examinations and optical coherence tomography (OCT) testing, and visual acuity was testing using the Early Treatment of Diabetic Retinopathy Study (ETDRS) eye chart. 

At the conclusion of the trial in January 2018, Ohr CEO Jason Slakter commented, “We are very disappointed with the outcome of the MAKO study.” Why? Subjects using squalamine only achieved a mean gain of 8.33 letters from baseline versus 10.58 letters from baseline with Lucentis monotherapy, thus failing to meet the primary efficacy endpoint: mean visual acuity gain at 9 months. 

Squalamine is an interesting chemical from an unusual source. Does it still have a role to play in improving eye health?

Related Content

Newsletters

Receive the latest Ophthalmology news, personalities, education, and career development – weekly to your inbox.

Newsletter Signup Image

False

Advertisement

False

Advertisement

Explore More in Ophthalmology

Dive deeper into the world of Ophthalmology. Explore the latest articles, case studies, expert insights, and groundbreaking research.

False

Advertisement
The Ophthalmologist
Subscribe

About

  • About Us
  • Work at Conexiant Europe
  • Terms and Conditions
  • Privacy Policy
  • Advertise With Us
  • Contact Us

Copyright © 2025 Texere Publishing Limited (trading as Conexiant), with registered number 08113419 whose registered office is at Booths No. 1, Booths Park, Chelford Road, Knutsford, England, WA16 8GS.

Disclaimer

The Ophthalmologist website is intended solely for the eyes of healthcare professionals. Please confirm below: