Subscribe to Newsletter
Subspecialties Cornea / Ocular Surface, Glaucoma

Dua for the Price of One

Harminder Dua

Last year, a new  layer of the cornea was described by Harminder Dua and colleagues at Nottingham University, UK. Comprised of thin collagen plates, “Dua’s layer” is just fifteen microns thick yet it is incredibly tough. The finding had implications for corneal surgery and the understanding of corneal diseases (1). At the time, we asked the eminent professor, “Do you think we now know the complete anatomy of the eye, or is there more to be discovered?” His reply was, “Well, as a follow-up to this paper, we will be introducing another little surprise.”

We know have that “little surprise”. Using electron microscopy on human donor eyes, the Nottingham team examined Dua’s Layer at the extreme periphery of the cornea. There, they discovered, the collagen fibers of the layer branch out to form a meshwork. The core of the trabecular meshwork is in fact an extension of Dua’s Layer (2).

“Many surgeons who perform lamellar corneal transplant recognize this layer as an important part of the surgical anatomy of the cornea,” Dua says. “This new finding resulting from a study of the microanatomy of the periphery of the layer could have significance beyond corneal surgery.”

It certainly opens up a new avenue of research into glaucoma, where it may offer new clues as to why the trabecular meshwork malfunctions in this sight-robbing disease. Moorfield-based David Garway-Heath, the International Glaucoma Association Professor of Ophthalmology said of the discovery, “Trabecular meshwork dysfunction that results in impaired outflow of aqueous humor is the main cause of raised IOP in glaucoma. Knowledge of the anatomical origin and organization of the trabecular meshwork will aid our understanding of its function and may stimulate new research into modulating trabecular meshwork  function which, in turn, could lead to new therapies”.

Receive content, products, events as well as relevant industry updates from The Ophthalmologist and its sponsors.

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. “To Galen, Mundinus and Tulp, Add Dua”, The Ophthalmologist, 1, 40-41 (2013)
  2. H. Dua et al., “The Collagen Matrix of the Human Trabecular Meshwork is an Extension of the Novel Pre-Descemet’s Layer (Dua’s Layer)”, Br. J. Ophthalmol. (2014). Epub ahead of print. doi:10.1136/bjophthalmol-2013-304593.
About the Author
Mark Hillen

I spent seven years as a medical writer, writing primary and review manuscripts, congress presentations and marketing materials for numerous – and mostly German – pharmaceutical companies. Prior to my adventures in medical communications, I was a Wellcome Trust PhD student at the University of Edinburgh.

Related Case Studies
The Missing Piece of the Dry Eye Puzzle

| Contributed by Quidel

Uncovering Ocular Comorbidity

| Contributed by Quidel

Finding Ocular Surface Inflammation

| Contributed by Quidel

Related Product Profiles
Subspecialties Cornea / Ocular Surface
Tear Osmolarity – Empowering. Established. Essential.

| Contributed by TearLab

Subspecialties Cornea / Ocular Surface
Preservative-Free Cyclosporine 0.1% Ophthalmic Emulsion

| Contributed by ImprimisRx

Product Profiles

Access our product directory to see the latest products and services from our industry partners

Most Popular
Register to The Ophthalmologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Ophthalmologist magazine



The Ophthalmologist website is intended solely for the eyes of healthcare professionals. Please confirm below: