Cookies

Like most websites The Ophthalmologist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Subspecialties Cornea/Ocular Surface

Decorin: Strengthening the Cornea Without UV Light?

At a Glance

  • The most effective form of corneal collagen cross-linking (CXL) requires corneal epithelial cell abrasion,  riboflavin soaking (30 minutes), constant riboflavin application during UV light exposure for an additional 30 minutes
  • Decorin core protein is a naturally-occurring proteoglycan that, when applied to the cornea, could have a similar strengthening and cross-linking effect as UV-A riboflavin CXL
  • Some preclinical corneal biomechanical evaluations of decorin core protein have been conducted on pig and donor human corneal pairs
  • The results so far are encouraging, with decorin-treated corneas showing similar biomechanical changes to what would be expected with standard UV-A riboflavin CXL treatment

Corneal collagen cross-linking (CXL) with ultraviolet (UV)-A light and riboflavin is a relatively young procedure that has made a huge impact for the treatment of keratoconus and other corneal ectasias. UV-A light activates riboflavin, producing oxygen radicals that induce the formation of collagen cross-links, mechanically strengthening the cornea, and increasing its resistance to proteases that are upregulated in these corneal diseases.

Enjoy our FREE content!

Log in or register to read this article in full and gain access to The Ophthalmologist’s entire content archive. It’s FREE and always will be!

Login if you already created an account

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Ophthalmologist magazine
Register

Or Login as a Guest or via Social Media

Newsletter

Send me the latest from The Ophthalmologist.

Sign up now

Most Popular

Register here

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Ophthalmologist magazine

Register