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Subspecialties Cornea / Ocular Surface

CXL Excels

Corneal collagen cross linking (CXL) with ultraviolet (UV)-A light and riboflavin is a well-established treatment for corneal ecstasias and keratoconus. But are we using it to its full potential? This was the question pondered by Geneva and Lausanne-based researchers, who believe there are other conditions that might benefit from CXL, such as pellucid marginal degeneration and peripheral ulcers. However, these diseases require decentered, eccentric illumination profiles, meaning that partially irradiating the limbus with (potentially mutagenic) UV-A light is unavoidable. Corneal limbal stem cells are needed to repair the corneal epithelium following epi-off CXL, and damage affecting their regenerative capabilities would be detrimental to recovery. So the big question was, does UV-A light harm corneal stem cells? According to the researchers, no (1).

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About the Author

Roisin McGuigan

I have an extensive academic background in the life sciences, having studied forensic biology and human medical genetics in my time at Strathclyde and Glasgow Universities. My research, data presentation and bioinformatics skills plus my ‘wet lab’ experience have been a superb grounding for my role as a deputy editor at Texere Publishing. The job allows me to utilize my hard-learned academic skills and experience in my current position within an exciting and contemporary publishing company.

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