Central Corneal Connection
A genetic link between CCT and glaucoma has been identified
Ruth Steer |
“What does a transcription factor expressed in the cornea have to do with glaucoma?” asks Eldon Geisert Jr, Professor of Ophthalmology at Emory Eye Center, Atlanta, Georgia, USA. Well, Geisert and his team have identified that the transcription factor in question – POU6F2 – could be a risk factor for primary open angle glaucoma (POAG) (1).
Thinner corneas are a well-known risk factor for POAG, but no one has really understood how or why, because of the multiple confounding genetic and environmental factors – and the need for extremely large sample sizes for genetic analysis. Inspired to understand more about the mechanisms of neuronal death in glaucoma, Geisert and his team set out to investigate the potential molecular link between central corneal thickness (CCT) and this process with a more feasible approach.
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