Age-related Methylation Degeneration
The largest ever study of DNA methylation patterns in the retinal pigment epithelium from individuals with age-related macular degeneration identifies three targets for functional studies and drug development work
Patients with neovascular AMD rely on intravitreal injections of anti-VEGF – an onerous treatment which slows, but does not prevent, vision loss. Those with the non-neovascular form are similarly poorly served: they have no therapeutic options beyond vitamin supplements, and in the UK national health service, they are not even regularly monitored. Indeed, patients with non-neovascular AMD – despite representing the largest AMD patient group – have seen no significant change in their prognosis for decades. Yet interruption of the disease in this group of patients – as well as being desirable in itself – would avoid the undesirable treatments and unavoidable consequences associated with progression to neovascular AMD. Surely the early/intermediate AMD stages deserve more attention?
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