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Subspecialties Cornea / Ocular Surface, Basic & Translational Research

2P-CXL: the Final Frontier?

Ever since the first astigmatic keratotomy was performed over a century ago, ophthalmologists have known that changes in corneal biomechanics have refractive effects. Corneal collagen cross-linking (CXL) strengthens the cornea, and even it can be used for this purpose – for example, Avedro’s PiXL promises to correct refractive errors with selective cross-linking. But what’s next?

Researchers from the Wellman Center for Photomedicine at Massachusetts General Hospital have revealed two-photon CXL (2P-CXL) (1). The paper’s corresponding author, Seok-Hyun (Andy) Yun explains, “In optical imaging, two-photon microscopy has become very popular, and we wanted to take advantage of these benefits and use them to improve conventional CXL, which is based on one-photon absorption of UV light.” In their study, the team selectively stiffened bovine corneal tissue in three dimensions using just riboflavin and 810 nm light pulses from femtosecond laser (1).

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