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The Ophthalmologist / Issues / 2026 / April / Hydrus®: The Long-Term Evidence
Research & Innovations Cataract Glaucoma Sponsored

Hydrus®: The Long-Term Evidence

Professor Gus Gazzard* outlines the five-year results of the HORIZON study, evaluating the safety and efficacy of the Hydrus® Microstent

Sponsored By Alcon 4/24/2026 6 min read

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Clinical Scorecard: Hydrus: The Long-Term Evidence

At a Glance

CategoryDetail
ConditionGlaucoma
Key MechanismsReduction of intraocular pressure (IOP) and medication usage when combined with cataract surgery.
Target PopulationPatients undergoing cataract surgery with glaucoma.
Care SettingOphthalmology clinics and surgical centers.

Key Highlights

  • 77.2% of Hydrus patients achieved an unmedicated IOP reduction of ≥20% from baseline at 24 months.
  • 59% of Hydrus patients remained entirely medication-free at five years.
  • Hydrus significantly reduced day-one postoperative IOP spikes (1.4% vs. 14.4% in control).
  • Fewer patients in the Hydrus group required later incisional glaucoma surgery over five years.
  • Long-term follow-up enhances reliability and robustness of data.

Guideline-Based Recommendations

Diagnosis

  • Evaluate IOP and medication usage in glaucoma patients preoperatively.

Management

  • Consider Hydrus Microstent implantation during cataract surgery for glaucoma management.

Monitoring & Follow-up

  • Follow up on IOP levels and medication needs at regular intervals post-surgery.

Risks

  • Monitor for postoperative IOP spikes, especially on day one.

Patient & Prescribing Data

Patients with glaucoma undergoing cataract surgery.

Hydrus Microstent may reduce the need for additional glaucoma surgeries and medication.

Clinical Best Practices

  • Wash out medications before measuring IOP to assess true surgical effect.
  • Educate patients on the potential benefits of Hydrus in reducing medication dependency.

References

  • HORIZON Study Results

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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