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The Ophthalmologist / Issues / 2025 / August / Modernizing Endpoints in Ophthalmic Clinical Trials / Summary
Anterior Segment Opinions Cornea

Modernizing Endpoints in Ophthalmic Clinical Trials

Why workflow integration and real-time data validation matters

By Andrew D. Pucker, Ram Yalamanchili 8/4/2025 4 min read

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article Full Article subject Summary summarize Notecard
Ophthalmic clinical trials face significant challenges due to outdated workflows and manual endpoint collection methods that lead to high variability and inefficiencies. Experts advocate for an integrated approach using AI-driven systems to standardize assessments and enhance trial execution. Such innovations can mitigate protocol deviations, reduce costs, and streamline training of investigators, ultimately improving data quality and outcomes in clinical research. The integration of modern technology is crucial for the future of successful clinical trials.

About the Author(s)

Andrew D. Pucker

Andrew Pucker is Vice President of Clinical Development at Mintra Health. He earned his OD, MS, and PhD degrees from The Ohio State University, and he is the former director of the UAB Eye Care Myopia Control Clinic. He has received research or consulting support from Alcon Research, LLC, Art Optical, Haymarket Media, Inc, and Hanall Biopharma in the past year.

More Articles by Andrew D. Pucker

Ram Yalamanchili

Ram Yalamanchili is CEO and founder of Tilda Research, where he builds AI teammates for clinical research.

More Articles by Ram Yalamanchili

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