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Modernizing Endpoints in Ophthalmic Clinical Trials

Why workflow integration and real-time data validation matters

By Andrew D. Pucker, Ram Yalamanchili 8/4/2025 4 min read

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Ophthalmic trials are hindered by outdated workflows.
Manual endpoints lead to variability and financial inefficiencies.
AI can transform data collection processes.
Real-time validation can prevent protocol deviations.
Integration of all trial systems simplifies the process.
Improved training methods can enhance investigator proficiency.
Modern operations are necessary for clinical trials. AI must complement, not replace, clinical judgment.

About the Author(s)

Andrew D. Pucker

Andrew Pucker is Vice President of Clinical Development at Mintra Health. He earned his OD, MS, and PhD degrees from The Ohio State University, and he is the former director of the UAB Eye Care Myopia Control Clinic. He has received research or consulting support from Alcon Research, LLC, Art Optical, Haymarket Media, Inc, and Hanall Biopharma in the past year.

Ram Yalamanchili

Ram Yalamanchili is CEO and founder of Tilda Research, where he builds AI teammates for clinical research.

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Modernizing Endpoints in Ophthalmic Clinical Trials

Why workflow integration and real-time data validation matters

About the Author(s)

Andrew D. Pucker

Ram Yalamanchili

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