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Welcome to January's issue. Upfront’s topics range from the problems high myopes have with accommodative IOLs, to better isolation of RGCs with a FACS machine. Pearse Keane and Alex Walsh envisage the future eye exam: binocular OCT. In Practice sees Mauricio Perez explain iris defect repair, and Burkhard Dick reviews the IC-8 IOL’s real-world outcomes. NextGen explores gene editing therapies, and Mark Talary reviews the impact of the new EU Medical Device Directive in Profession, and we Sit Down With John Marshall: The Cyberman’s Apprentice.