Subscribe to Newsletter
Business & Profession Retina, Business and Innovation, Diabetes

Lowering Lipids – and AMD

Collage images supplied from Rawpixel.com

AMD is the leading cause for severe visual impairment and blindness in high-income countries, particularly in the over-55 age group. In Europe alone, 67 million people are affected by AMD (1) and this figure will only increase as the population continues to age. Despite the condition’s growing prevalence, few preventative interventions are available.

However, new research offers a promising pathway for the future of AMD. In a meta-analysis of 14 population-based and hospital-based European study cohorts, researchers found an association between the systemic use of lipid-lowering drugs (LLDs) and antidiabetic drugs and lower AMD prevalence. As well as lowering serum levels of low-density lipoprotein and triglycerides, some LLDs also have anti-inflammatory and antioxidant properties that affect AMD pathogenesis (1).

Although previous research has investigated the impact of antidiabetic drugs on AMD, these studies conflicted and were not transferable to the general population because they included diabetic patients whose condition could have interfered with AMD pathophysiology. This new study marks the first that meta-analyzes individual-level data, rather than aggregated results.

Despite the study’s promising outcomes, the authors stress its limitations and call for further research. The limitations include issues such as cross-sectional data collection that didn’t assess causality or risk and the fact the patients involved were taking LLDs or antidiabetic drugs for primary purposes, making it impossible to evaluate the drugs’ effects on healthy individuals. Combining these limitations with previous controlled trials that failed to show a causal relationship, it is clear that – although this research paves a new path for the future of AMD treatment – more longitudinal research is needed to better understand the relationship between AMD and systemic medication.

Receive content, products, events as well as relevant industry updates from The Ophthalmologist and its sponsors.

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. MM Mauschitz et al., “Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans,” Br J Ophthalmol, [Online ahead of print] (2022). PMID: 36344262.
About the Author
Sarah Healey

Communicating stories in a way that is accessible to all was one of the focal points of my Creative Writing degree. Although writing magical realism is a fun endeavor (and one I still dabble in), getting to the heart of human stories has always been the driving motivator behind my writing. At Texere, I am able to connect with the people behind scientific breakthroughs and share their stories in a way that is impactful and engaging.

Related Product Profiles
Uncover the Unique DNA of SPECTRALIS®

| Contributed by Heidelberg Engineering

Subspecialties Retina
ForeseeHome® – remote monitoring to help detect wet AMD earlier and improve outcomes

| Contributed by Notal Vision

Product Profiles

Access our product directory to see the latest products and services from our industry partners

Here
Most Popular
Register to The Ophthalmologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Ophthalmologist magazine

Register

Disclaimer

The Ophthalmologist website is intended solely for the eyes of healthcare professionals. Please confirm below: