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Five Things We Learned This Month:

Five Things We Learned This Month:

1. Drusen Contain Calcium Spheres

Tiny spherules of hydroxyapatite – bone mineral – have been discovered in drusen, and researchers suspect they might initiate and catalyze drusen and basal laminar deposit formation, by providing a scaffold for common drusen proteins to adhere.

2. The First Mutation in Heritable OMS Has Been Found

A gene, PNPLA6, thought to be responsible for certain heritable cases of Leber Congenital Amaurosis and Oliver-McFarlane Syndrome has just been identified – and helps us better understand some of the cellular processes involved in retinal degeneration.

3. Up To 15 percent of Patients Are “Poor Responders” to Anti-VEGF

A recent study identified one possible cause of poor response to anti-VEGF drugs in the retina: obstructive sleep apnea (OSA). Patients with AMD and DME are far more likely to respond poorly to bevacizumab if they also have a high risk of OSA.

4. A Quarter of all Published Articles on Cone Dystrophy are Basic Research

This month, The Ophthalmologist benchmarked the last five years of PubMed-listed abstracts on cone dystrophy. We found that 25 percent of all articles were basic research, 38 percent were case reports/ case series, and just two percent were clinical trials.

5. The Best Ways to Assess Postoperative Visual Performance

Assessing patients’ refraction following monofocal IOL placement was relatively simple –but it’s a whole different ballgame with the advanced optics of premium IOLs. Florian Kretz shared his tips for optimal assessment.

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