Under the Lid
Bringing clarity to the mechanisms behind AMD
Phoebe Harkin | | Interview
Researchers have shed new light on the link between type 1 choroidal neovascularization (CNV) and the localized progression of atrophy in AMD. The team from the University of Bonn, Germany, analyzed a total of 98 eyes subdivided into three categories: RPE atrophy with treatment-naive quiescent CNV, RPE atrophy with a history of exudative CNV, and RPE atrophy without evidence of coexisting CNV. Atrophy was delineated on the basis of serial fundus-autofluorescence and infrared-reflectance images, with researchers finding markedly reduced RPE atrophy progression in areas co-localizing with quiescent and exudative type 1 CNV.
The takeaway? Type 1 CNV may have a potential protective effect on the RPE. Monika Fleckenstein from the University of Bonn, Germany, and the University of Utah, Salt Lake City, USA, tells us more about the clinical implications of the research.
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