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Subspecialties Retina, Basic & Translational Research, Business and Innovation

Pouring Oil on Troubled Retinas

At a Glance

  • Replacing the vitreous with silicone oil can reduce scar tissue formation in vitreoretinopathy and diabetic retinopathy, but attempts to combine the oil with pharmaceuticals have not yet been successful
  • A multidisciplinary team at the University of Liverpool, UK, is working on achieving controlled drug release from silicone tamponades to prevent retinal scarring
  • Milestones of the research so far include choosing the right model drug and determining its solubility in oil, as well as modulating the release kinetics of oil-drug combinations
  • The team has proven that modified silicone oils are non-toxic to relevant cells, they enhance drug solubility and extend drug release.

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About the Author

Victoria Kearns

Lecturer in Ocular Biomaterials, University of Liverpool, UK.

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